Holoprosencephaly, ICBDSR Report 2024

Programs grouped by geography and decreasing prevalence, data 2015-2020 (some programs with fewer years), prevalence per 10,000 births
Legend: Hosp, hospital-based; Pop, population-based; T-incl, terminations of pregnancy included (T-not, not included)
country Program Ascertainment Births Cases Prevalence 95% CI Prevalence Chart
Europe & Central Asia
Italy Italy Lombardy CMRL Pop, T-incl 12,114 6 5.0 1.8 - 10.8 112
France France Paris Pop, T-incl 147,551 41 2.8 2 - 3.8 42
Netherlands Northern Netherlands Pop, T-incl 91,261 22 2.4 1.5 - 3.6 42
France France REMERA Pop, T-incl 337,271 72 2.1 1.7 - 2.7 32
France France Brittany Pop, T-incl 194,447 41 2.1 1.5 - 2.9 32
United Kingdom England NCARDRS Pop, T-incl 2,036,067 386 1.9 1.7 - 2.1 22
Czechia Czech Republic Pop, T-incl 339,034 55 1.6 1.2 - 2.1 21
Italy Italy Tuscany RTDC Pop, T-incl 146,815 23 1.6 1 - 2.4 21
Germany Germany Saxony Anhalt Pop, T-incl 103,943 16 1.5 0.9 - 2.5 21
Finland Finland Pop, T-incl 254,007 39 1.5 1.1 - 2.1 21
Italy Italy Emilia Romagna IMER Pop, T-incl 199,036 25 1.3 0.8 - 1.9 21
Ukraine Ukraine OMNI Net Hosp, T-incl 130,244 14 1.1 0.6 - 1.8 21
Italy Italy Campania BDRCam Pop, T-incl 151,828 16 1.1 0.6 - 1.7 21
Italy Italy Veneto Pop, T-incl 147,708 15 1.0 0.6 - 1.7 21
Sweden Sweden Pop, T-incl 701,879 54 0.8 0.6 - 1 11
Malta Malta MCAR Pop, T-not 22,377 1 0.4 0 - 2.5 20
Slovakia Slovak Republic Pop, T-not 343,485 8 0.2 0.1 - 0.5 00
Latin America & Caribbean
Mexico Mexico RYVEMCE Hosp, T-not 26,648 10 3.8 1.8 - 6.9 72
Chile Chile RENACH Hosp, T-incl 372,524 86 2.3 1.8 - 2.9 32
Argentina Argentina RENAC Hosp, T-not 1,689,069 353 2.1 1.9 - 2.3 22
Costa Rica Costa Rica CREC Pop, T-not 403,647 59 1.5 1.1 - 1.9 21
- South America South America ECLAMC Hosp, T-not 330,135 23 0.7 0.4 - 1 10
Colombia Colombia Bogotá Pop, T-incl 233,100 11 0.5 0.2 - 0.8 10
Colombia Colombia Cali Pop, T-incl 55,537 2 0.4 0 - 1.3 10
North America
Canada Canada Alberta ACASS Pop, T-incl 317,752 87 2.7 2.2 - 3.4 32
United States USA Iowa IRCID Pop, T-not 155,651 30 1.9 1.3 - 2.8 31
United States USA Texas BDES Pop, T-incl 1,946,187 250 1.3 1.1 - 1.5 21
Canada Canada National CCASS Pop, Other 1,717,113 159 0.9 0.8 - 1.1 11
Middle East & North Africa
Iran Iran TRoCA Hosp, T-incl 37,552 2 0.5 0.1 - 1.9 20
Israel Israel IBDSP Hosp, T-not 203,574 8 0.4 0.2 - 0.8 10